?Frequency of CYP2D6*3 and *4 and metabolizer phenotypes in three mestizo Peruvian populations

Wild type genotypes ( CYP2D6 ) and their allelic variants have been described in a sample of Peruvian mestizo population. The global allele frequency was 0.015 for CYP2D6*3 0.051 CYP2D6*4 . percentages were 97% CYP2D6*1/*1 3.0% CYP2D6*1/*3 ; 90.60% , 8.55% CYP2D6*1/*4 0.85% CYP2D6*4/*4 frequencies the Lima subpopulations 0.022 0.010 Junin; 0.048, 0.060, 0.050 residents Lima, Junín, Tacna, respectively. Hardy-Weinberg equilibrium test studied population showed that both are equilibrium, p <.05. metabolizer phenotype inferred according to genotypes: 11.54% classified as intermediate metabolizers (*1/*3 or *1/*4) poor (*4/*4). It is concluded alleles low compared Latin American tricontinental population, due natural evolution, which manifested by decreased metabolic activity, same relevant clinical practice.